Kasper Lloyd, Courret Nathalie, Darche Sylvie, Luangsay Souphalone, Mennechet Franck, Minns Laurie, Rachinel Nicolas, Ronet Catherine, Buzoni-Gatel Dominique
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Int J Parasitol. 2004 Mar 9;34(3):401-9. doi: 10.1016/j.ijpara.2003.11.023.
Toxoplasma gondii, an intracellular parasite infects the host through the oral route. Infection induces a cascade of immunological events that involve both the components of the innate and adaptative immune responses. Alteration of the homeostatic balance of infected intestine results in an acute inflammatory ileitis in certain strains of inbred mice. Both the infected enterocytes as well as the CD4 T cells from the lamina propria produce chemokines and cytokines that are necessary to clear the parasite whereas CD8 intraepithelial lymphocytes secrete transforming growth factor beta that reduces the inflammation. In this review, we describe the salient features of this complex network of interactions among the different components of the gut-associated lymphoid tissue cell population that are induced after oral infection with T. gondii.
刚地弓形虫是一种细胞内寄生虫，通过口腔途径感染宿主。感染引发一系列免疫事件，涉及固有免疫和适应性免疫反应的组成部分。感染肠道内稳态平衡的改变在某些近交系小鼠品系中导致急性炎症性回肠炎。被感染的肠上皮细胞以及固有层的CD4 T细胞都会产生清除寄生虫所需的趋化因子和细胞因子，而上皮内CD8淋巴细胞分泌转化生长因子β以减轻炎症。在这篇综述中，我们描述了刚地弓形虫经口感染后诱导的肠道相关淋巴组织细胞群体不同组成部分之间这种复杂相互作用网络的显著特征。
