Buzoni-Gatel Dominique, Schulthess Julie, Menard Laurence C, Kasper Lloyd H
Réponses Précoces aux Parasites et Immunopathologie, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France.
Cell Microbiol. 2006 Apr;8(4):535-44. doi: 10.1111/j.1462-5822.2006.00692.x.
Protozoan parasites that gain access to the host through the mucosal tissue of the alimentary tract may influence the development of intestinal inflammatory disorders. Despite the diversity of the extracellular and intracellular protozoan pathogens discussed in this review, our current understanding of the mechanisms involved in the immune response indicates that a common exuberant immune response to rid the host of these agents is elicited. This robust inflammatory response is orchestrated both by cells from parenchymatous origin such as intestinal epithelial cells and by cells from the haematopoietic system such as macrophages, dendritic cells and lymphocytes. This inflammatory immune response is controlled by a series of regulatory mechanisms in most species. When this balance is no longer evident, an inflammation of the intestine may occur, leading to acute gastritis and diarrhoea and that would add pathological effects to those because of the pathogen itself.
通过消化道黏膜组织进入宿主的原生动物寄生虫可能会影响肠道炎症性疾病的发展。尽管本综述中讨论的细胞外和细胞内原生动物病原体具有多样性，但我们目前对免疫反应所涉及机制的理解表明，会引发一种常见的、旨在清除宿主体内这些病原体的旺盛免疫反应。这种强烈的炎症反应是由实质来源的细胞（如肠道上皮细胞）和造血系统的细胞（如巨噬细胞、树突状细胞和淋巴细胞）共同协调的。在大多数物种中，这种炎症免疫反应受一系列调节机制的控制。当这种平衡不再明显时，可能会发生肠道炎症，导致急性胃炎和腹泻，这将给病原体本身所造成的病理影响增添更多影响。
