Salamanca J, Benito A, García-Peñalver C, Azorín D, Ballestín C, Rodríguez-Peralto J L
Department of Pathology, 12 de Octubre University Hospital, Avenida de Córdoba s/n, 28041 Madrid, Spain.
J Cutan Pathol. 2004 Apr;31(4):341-5. doi: 10.1111/j.0303-6987.2004.0184.x.
Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC.
We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease.
继发于膀胱移行细胞癌（TCC）的阴茎头乳腺外佩吉特病罕见，文献中仅报道了少数病例。我们报告两例新病例，其中一例在诊断膀胱TCC之前被发现。
我们描述了两例阴茎头TCC上皮内播散患者的临床病理特征以及肿瘤的组织化学和免疫组织化学特征。
光镜检查发现肿瘤性大的淡染细胞上皮内增殖，主要位于上皮的基底层和副基底层。佩吉特样细胞对黏液物质呈细胞质阳性染色，对CK20呈免疫反应性。对先前报道的病例进行了回顾并讨论了鉴别诊断。
由于许多良性和恶性阴茎头病变在临床上可能相似，因此有必要进行组织学研究以正确诊断原发性病变，并及时检测最初表现为佩吉特病的潜在无症状内脏恶性肿瘤。
