Diwu Z, Zhang C, Lown J W
Department of Chemistry, University of Alberta, Edmonton, Canada.
Anticancer Drug Des. 1993 Apr;8(2):129-43.
Perylenequinonoid pigments have demonstrated several photodynamic therapeutic advantages over the commonly used hematoporphyrin derivatives. Certain new amino-substituted hypocrellin B derivatives have been prepared, and both direct and reductive aminations of hypocrellin B are described. The photophysical and photochemical properties of the amino-substituted hypocrellin B derivatives were investigated, and their significantly enhanced red absorptivities and strong 1O2-generating functions qualify them as promising photodynamic therapeutic agents. In addition, the superoxide anion radical was also determined to be implicated in the photosensitization of the amino-substituted hypocrellin B derivatives.
苝醌类色素已显示出比常用的血卟啉衍生物具有多种光动力治疗优势。制备了某些新的氨基取代竹红菌素B衍生物，并描述了竹红菌素B的直接胺化和还原胺化反应。研究了氨基取代竹红菌素B衍生物的光物理和光化学性质，其显著增强的红光吸收率和强大的单线态氧生成功能使它们成为有前景的光动力治疗剂。此外，还确定超氧阴离子自由基也参与了氨基取代竹红菌素B衍生物的光敏化过程。
