新型潜在钙通道调节剂：微波辐射下含两个吡啶、嘧啶、吡啶酮、喹啉和吖啶单元化合物的设计与合成
New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation.
作者信息
Tu Shujiang, Miao Chunbao, Fang Fang, Youjian Feng, Li Tuanjie, Zhuang Qiya, Zhang Xiaojing, Zhu Songlei, Shi Daqing
机构信息
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Jiangsu, Xuzhou, Jiangsu 221009, People's Republic of China.
出版信息
Bioorg Med Chem Lett. 2004 Mar 22;14(6):1533-6. doi: 10.1016/j.bmcl.2003.12.092.
The synthesis of bifunctional pyridine, pyrimidine, pyridone, quinoline and acridine derivatives was investigated using dialdehyde as a precursor. A rapid and efficient method was developed for the synthesis of a range of bifunctional monocyclic, bicyclic and tricyclic products related to 1,4-DHPs with the aim of finding new classes of biologically active compounds.
以二醛为前体，对双功能吡啶、嘧啶、吡啶酮、喹啉和吖啶衍生物的合成进行了研究。开发了一种快速有效的方法来合成一系列与1,4-二氢吡啶相关的双功能单环、双环和三环产物，旨在寻找新的生物活性化合物类别。
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