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新型潜在生物活性化合物：微波辐射下N-取代的4-芳基-4,6,7,8-四氢喹啉-2,5(1H,3H)-二酮的设计与高效合成

New potential biologically active compounds: design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation.

作者信息

Tu Shujiang, Zhu Xiaotong, Zhang Jinpeng, Xu Jianing, Zhang Yan, Wang Qian, Jia Runhong, Jiang Bo, Zhang Junyong, Yao Changsheng

机构信息

Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Xuzhou, Jiangsu 221009, PR China.

出版信息

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2925-8. doi: 10.1016/j.bmcl.2006.03.011. Epub 2006 Mar 24.

DOI:10.1016/j.bmcl.2006.03.011
PMID:16563758
Abstract

A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening.

摘要

通过微波辐射下的快速一锅四组分反应合成了一系列N-取代的4-芳基-4,6,7,8-四氢喹啉-2,5(1H,3H)-二酮。该方法具有产率优异（82-96%）和反应时间短（4-9分钟）的优点。我们为生物医学筛选提供了新的一系列潜在生物活性化合物。

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