抗肿瘤剂。第232部分：环亚硫酸酯鬼臼毒素类似物作为新型抗肿瘤剂原型的合成。

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.

作者信息

Xiao Zhiyan, Han Shiqing, Bastow Kenneth F, Lee Kuo-Hsiung

机构信息

Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

出版信息

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1581-4. doi: 10.1016/j.bmcl.2003.12.096.

DOI:10.1016/j.bmcl.2003.12.096

PMID:15006408

Abstract

An 11,13-O,O'-cyclosulfite GL-331 analogue (7) was synthesized in six steps from podophyllotoxin and evaluated as a potential antitumor agent. Compound 7 was significantly cytotoxic against human tumor cell lines, but showed no inhibition against human DNA topoisomerase II in vitro. This compound represents a novel prototype of antitumor podophyllotoxin analogues.

摘要

一种11,13 - O,O'-环亚硫酸酯GL - 331类似物（7）由鬼臼毒素经六步合成，并作为一种潜在的抗肿瘤药物进行了评估。化合物7对人肿瘤细胞系具有显著的细胞毒性，但在体外对人DNA拓扑异构酶II没有抑制作用。该化合物代表了一种新型的抗肿瘤鬼臼毒素类似物原型。