新型4β-苯胺基和4β-亚氨基取代鬼臼毒素类似物的合成及生物学评价
Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.
作者信息
Kamal Ahmed, Gayatri N Lakshmi, Reddy D Rajasekhar, Mohan Reddy P S Murali, Arifuddin M, Dastidar Sunanda G, Kondapi Anand K, Rajkumar M
机构信息
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India.
出版信息
Bioorg Med Chem. 2005 Nov 15;13(22):6218-25. doi: 10.1016/j.bmc.2005.06.032. Epub 2005 Aug 2.
A series of C-4-anilino- and C-4-imido-substituted new podophyllotoxin congeners have been designed, synthesized, and evaluated for their cytotoxicity and DNA topoisomerase-II (topo-II) inhibition potential. Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity.
设计、合成了一系列C-4-苯胺基和C-4-酰亚胺取代的新鬼臼毒素类似物，并对其细胞毒性和DNA拓扑异构酶-II（拓扑异构酶-II）抑制潜力进行了评估。其中一些化合物已表现出有前景的体外抗癌和拓扑异构酶-II抑制活性。
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