• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

4β-[(4-取代)-1,2,3-三唑-1-基]鬼臼毒素类似物作为抗肿瘤药物的设计、合成及生物学测试

Design, synthesis, and biological testing of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues as antitumor agents.

作者信息

Reddy Pitta B, Paul David V, Agrawal Satyam K, Saxena Ajit K, Kumar Halmuthur M S, Qazi Ghulam N

机构信息

Department of Synthetic Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi, India.

出版信息

Arch Pharm (Weinheim). 2008 Feb;341(2):126-31. doi: 10.1002/ardp.200700116.

DOI:10.1002/ardp.200700116
PMID:18214838
Abstract

A series of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4beta-azido podophyllotoxin and C4beta-azido-4'-O-demethyl podophyllotoxin. All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 4'-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells.

摘要

通过使用铜（I）催化的1-O-炔丙基单糖与C4β-叠氮基鬼臼毒素和C4β-叠氮基-4'-O-去甲基鬼臼毒素的1,3-偶极环加成反应，以高区域选择性合成了一系列4β-[(4-取代)-1,2,3-三唑-1-基]鬼臼毒素类似物。对所有化合物针对六种人类癌细胞系的抗癌活性进行了评估。其中，4'-O-去甲基鬼臼毒素同系物主要对HCT-15（结肠）和DU-145（前列腺）细胞显示出有前景的抗癌活性。

相似文献

1
Design, synthesis, and biological testing of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues as antitumor agents.4β-[(4-取代)-1,2,3-三唑-1-基]鬼臼毒素类似物作为抗肿瘤药物的设计、合成及生物学测试
Arch Pharm (Weinheim). 2008 Feb;341(2):126-31. doi: 10.1002/ardp.200700116.
2
Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents.新型4β-[(4-取代)-1,2,3-三唑-1-基]鬼臼毒素作为潜在抗癌药物的研究。
Eur J Med Chem. 2008 Oct;43(10):2067-72. doi: 10.1016/j.ejmech.2007.09.015. Epub 2007 Sep 29.
3
Synthesis and biological evaluation of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents.4β-[(4-取代)-1,2,3-三唑-1-基]鬼臼毒素作为潜在抗癌剂的合成与生物学评价
Chem Biodivers. 2008 Sep;5(9):1792-802. doi: 10.1002/cbdv.200890168.
4
4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: design, synthesis and biological evaluation.4β-[(4-烷基)-1,2,3-三唑-1-基]鬼臼毒素类抗癌化合物的设计、合成与生物评价。
Eur J Med Chem. 2011 Jun;46(6):1983-91. doi: 10.1016/j.ejmech.2011.02.016. Epub 2011 Feb 24.
5
Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells.基于 1,2,3-三唑的鬼臼毒素类似物的半合成及生物评价作为诱导 HepG2 细胞凋亡的有效抗肿瘤剂。
Arch Pharm (Weinheim). 2012 Dec;345(12):945-56. doi: 10.1002/ardp.201100438. Epub 2012 Sep 5.
6
Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin.4β-(1,2,3-三唑-1-基)鬼臼毒素氨基甲酸酯衍生物的合成及其对人癌细胞的细胞毒性活性。
Eur J Med Chem. 2013 Jun;64:621-8. doi: 10.1016/j.ejmech.2013.03.068. Epub 2013 Apr 9.
7
Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.4'-去甲基表鬼臼毒素新型衍生物的合成及其细胞毒性活性
Bioorg Med Chem Lett. 2004 Oct 18;14(20):5063-6. doi: 10.1016/j.bmcl.2004.07.094.
8
A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α,β-2-propyne podophyllotoxin depicting potent cytotoxic activity.一种描绘出强大细胞毒性活性的4-α,β-2-丙炔鬼臼毒素的炔-叠氮环加成衍生物的汇聚合成。
Eur J Med Chem. 2014 Apr 22;77:47-55. doi: 10.1016/j.ejmech.2014.02.030. Epub 2014 Feb 14.
9
Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.新型4β-苯胺基和4β-亚氨基取代鬼臼毒素类似物的合成及生物学评价
Bioorg Med Chem. 2005 Nov 15;13(22):6218-25. doi: 10.1016/j.bmc.2005.06.032. Epub 2005 Aug 2.
10
Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.通过叠氮-炔环加成反应合成 4β-三唑-鬼臼毒素衍生物及其作为潜在抗肿瘤剂的生物评价。
Eur J Med Chem. 2011 Sep;46(9):4709-14. doi: 10.1016/j.ejmech.2011.07.024. Epub 2011 Jul 23.

引用本文的文献

1
Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity.鬼臼毒素的糖苷衍生物：合成、物理化学性质及细胞毒性
Drug Des Devel Ther. 2019 Oct 23;13:3683-3692. doi: 10.2147/DDDT.S215895. eCollection 2019.
2
Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents.新型生物素化鬼臼毒素衍生物作为潜在抗肿瘤药物的设计、合成及生物学评价
Front Chem. 2019 Jun 18;7:434. doi: 10.3389/fchem.2019.00434. eCollection 2019.
3
Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle) T.S. Ying.
生态因素对抗癌植物桃儿七（Sinopodophyllum hexandrum (Royle) T.S. Ying）中活性物质产生的影响
PLoS One. 2015 Apr 15;10(4):e0122981. doi: 10.1371/journal.pone.0122981. eCollection 2015.
4
Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides.4β-三唑-鬼臼毒素糖苷的合成及其抗癌活性
Nat Prod Bioprospect. 2015 Apr 14;5(2):83-90. doi: 10.1007/s13659-015-0057-3.
5
Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV.新型自旋标记鬼臼毒素衍生物作为潜在抗肿瘤药物的合成：第二十五部分。
Med Chem Res. 2014 Nov;23(11):4926-4931. doi: 10.1007/s00044-014-1042-9.
6
Design, synthesis, and cytotoxicity of perbutyrylated glycosides of 4β-triazolopodophyllotoxin derivatives.4β-三唑并鬼臼毒素衍生物的过丁酰化糖苷的设计、合成及细胞毒性
Molecules. 2015 Feb 16;20(2):3255-80. doi: 10.3390/molecules20023255.
7
Genetic diversity and structure of Sinopodophyllum hexandrum (Royle) Ying in the Qinling Mountains, China.中国秦岭地区桃儿七（Sinopodophyllum hexandrum (Royle) Ying）的遗传多样性与结构
PLoS One. 2014 Oct 15;9(10):e110500. doi: 10.1371/journal.pone.0110500. eCollection 2014.
8
Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents.C-4修饰的鬼臼毒素类似物作为强效抗肿瘤药物的最新进展。
Med Res Rev. 2015 Jan;35(1):1-62. doi: 10.1002/med.21319. Epub 2014 May 14.
9
Synthesis and anticancer activity of glucosylated podophyllotoxin derivatives linked via 4β-triazole rings.通过 4β-三唑环连接的葡萄糖基鬼臼毒素衍生物的合成及抗癌活性。
Molecules. 2013 Nov 13;18(11):13992-4012. doi: 10.3390/molecules181113992.