抗GQ1b抗体作为吉兰-巴雷综合征机械通气的预测因素。
Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barré syndrome.
作者信息
Kaida K, Kusunoki S, Kanzaki M, Kamakura K, Motoyoshi K, Kanazawa I
机构信息
Third Department of Internal Medicine, National Defense Medical College, Saitama-ken, University of Tokyo, Japan.
出版信息
Neurology. 2004 Mar 9;62(5):821-4. doi: 10.1212/01.wnl.0000113718.27729.43.
Compared with 87 unventilated patients with Guillain-Barré syndrome (GBS), 44 ventilated patients with GBS more frequently had multiple cranial nerve involvement (91 vs 50%; p < 0.001) and IgG anti-GQ1b antibody (27 vs 8%; p = 0.006). In GBS patients without ophthalmoparesis, the presence of IgG anti-GQ1b antibody was associated with respiratory failure (12 [3/25] vs 0% [0/67]; p = 0.04). The presence of the antibody may be a factor predictive of respiratory failure in GBS.
与87例未通气的吉兰-巴雷综合征（GBS）患者相比，44例通气的GBS患者更常出现多组颅神经受累（91%对50%；p<0.001）和IgG抗GQ1b抗体（27%对8%；p=0.006）。在无眼肌麻痹的GBS患者中，IgG抗GQ1b抗体的存在与呼吸衰竭相关（12例[3/25]对0%[0/67]；p=0.04）。该抗体的存在可能是GBS患者呼吸衰竭的一个预测因素。
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