Fadul Dalia, Rapelyea Jocelyn, Schwartz Arnold M, Brem Rachel F
Breast Imaging and Intervention, Department of Radiology, George Washington University, Washington, DC 20037, USA.
Breast J. 2004 Mar-Apr;10(2):141-5. doi: 10.1111/j.1075-122x.2004.21365.x.
The increased interest in the use of neoadjuvant chemotherapy for patients with locally advanced or large tumors at initial presentation necessitates the recognition of sequelae of this therapy. This article describes the interval appearance of malignant, linear-branching, microcalcifications during neoadjuvant chemotherapy for locally advanced breast cancer. Mammographically the malignant microcalcifications appeared only in the region of the breast where the primary tumor was found. Pathologically only a subpopulation of malignant cells responded to the chemotherapy, demonstrating viability of the majority of the tumor, with cell death only in the subpopulation. With the increased use of neoadjuvant chemotherapy, it is important to recognize previously undescribed mammographic findings secondary to this therapeutic approach.
对于初次就诊时患有局部晚期或大肿瘤的患者，使用新辅助化疗的兴趣日益增加，这就需要认识到这种治疗方法的后遗症。本文描述了局部晚期乳腺癌新辅助化疗期间恶性、线性分支微钙化的间期出现情况。在乳腺钼靶检查中，恶性微钙化仅出现在发现原发性肿瘤的乳腺区域。病理检查显示，只有一部分恶性细胞对化疗有反应，这表明大多数肿瘤细胞具有活力，只有这部分细胞发生了死亡。随着新辅助化疗使用的增加，认识到这种治疗方法继发的以前未描述的乳腺钼靶检查结果非常重要。
