• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

晚期乳腺癌新辅助化疗后恶性微钙化增加

Increased Malignant Microcalcifications after Neoadjuvant Chemotherapy in Advanced Breast Cancer.

作者信息

Shin Gi Won, Park Young Mi, Yoon Hye Kyoung, Jung Soo Jin, Kim Tae Hyun, Lee Anbok, Lee Seok Mo

机构信息

Department of Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

出版信息

J Breast Cancer. 2016 Dec;19(4):459-464. doi: 10.4048/jbc.2016.19.4.459. Epub 2016 Dec 23.

DOI:10.4048/jbc.2016.19.4.459
PMID:28053636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5204054/
Abstract

In patients with advanced breast cancer, most new calcifications detected on a mammogram after neoadjuvant chemotherapy are benign dystrophic calcifications, but this is not always observed. We present a patient with advanced breast cancer who had paradoxically increased malignant microcalcifications concomitant with primary tumor regression after undergoing neoadjuvant chemotherapy. After the neoadjuvant chemotherapy, the follow-up mammogram revealed that local, fine pleomorphic microcalcifications had markedly increased. Pathologically, these calcifications were ductal carcinoma . We concluded that, in patients with breast cancer undergoing neoadjuvant chemotherapy, newly developed microcalcifications on follow-up mammograms should be carefully evaluated, and any suspicious malignant microcalcifications should be included in surgical excision planning.

摘要

在晚期乳腺癌患者中，新辅助化疗后乳房X线摄影检测到的大多数新钙化灶是良性营养不良性钙化，但并非总是如此。我们报告了1例晚期乳腺癌患者，该患者在接受新辅助化疗后，原发肿瘤消退的同时恶性微钙化反而增多。新辅助化疗后，随访乳房X线摄影显示局部、细小的多形性微钙化显著增加。病理检查显示，这些钙化灶为导管癌。我们得出结论，对于接受新辅助化疗的乳腺癌患者，随访乳房X线摄影上新出现的微钙化灶应仔细评估，任何可疑的恶性微钙化灶都应纳入手术切除计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/2954ca22db11/jbc-19-459-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/0fd368b327e6/jbc-19-459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/4bdf4e327d54/jbc-19-459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/78598795f7dc/jbc-19-459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/855d5a775818/jbc-19-459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/b5183635fe90/jbc-19-459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/05b7b58b5deb/jbc-19-459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/eda587cb75ea/jbc-19-459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/2954ca22db11/jbc-19-459-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/0fd368b327e6/jbc-19-459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/4bdf4e327d54/jbc-19-459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/78598795f7dc/jbc-19-459-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/855d5a775818/jbc-19-459-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/b5183635fe90/jbc-19-459-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/05b7b58b5deb/jbc-19-459-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/eda587cb75ea/jbc-19-459-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b4/5204054/2954ca22db11/jbc-19-459-g008.jpg

相似文献

1
Increased Malignant Microcalcifications after Neoadjuvant Chemotherapy in Advanced Breast Cancer.晚期乳腺癌新辅助化疗后恶性微钙化增加
J Breast Cancer. 2016 Dec;19(4):459-464. doi: 10.4048/jbc.2016.19.4.459. Epub 2016 Dec 23.
2
Do Decreased Breast Microcalcifications After Neoadjuvant Chemotherapy Predict Pathologic Complete Response?新辅助化疗后乳腺微钙化减少能否预测病理完全缓解？
Clin Breast Cancer. 2020 Feb;20(1):e82-e88. doi: 10.1016/j.clbc.2019.05.015. Epub 2019 Jun 6.
3
Chemotherapy may eradicate ductal carcinoma in situ (DCIS) but not the associated microcalcifications.化疗可能根除导管原位癌（DCIS），但无法消除相关的微钙化。
Eur J Surg Oncol. 2017 Aug;43(8):1415-1420. doi: 10.1016/j.ejso.2017.04.011. Epub 2017 May 4.
4
Evaluation of malignancy risk stratification of microcalcifications detected on mammography: a study based on the 5th edition of BI-RADS.乳腺钼靶检查发现的微钙化灶恶性风险分层评估：一项基于第5版乳腺影像报告和数据系统（BI-RADS）的研究
Ann Surg Oncol. 2015 Sep;22(9):2895-901. doi: 10.1245/s10434-014-4362-6. Epub 2015 Jan 22.
5
Residual Mammographic Microcalcifications and Enhancing Lesions on MRI After Neoadjuvant Systemic Chemotherapy for Locally Advanced Breast Cancer: Correlation with Histopathologic Residual Tumor Size.局部晚期乳腺癌新辅助全身化疗后乳腺钼靶微钙化残留及MRI上强化病灶：与组织病理学残留肿瘤大小的相关性
Ann Surg Oncol. 2016 Apr;23(4):1135-42. doi: 10.1245/s10434-015-4993-2. Epub 2015 Dec 1.
6
Change in microcalcifications on mammography after neoadjuvant chemotherapy in breast cancer patients: correlation with tumor response grade and comparison with lesion extent.乳腺癌患者新辅助化疗后乳腺钼靶检查中微钙化的变化：与肿瘤反应分级的相关性及与病变范围的比较
Acta Radiol. 2019 Feb;60(2):131-139. doi: 10.1177/0284185118776491. Epub 2018 May 15.
7
[Mammographic findings in microcalcifications associated with breast cancer after neoadjuvant chemotherapy].[新辅助化疗后与乳腺癌相关的微钙化的乳腺钼靶检查结果]
Radiologia. 2007 Jan-Feb;49(1):37-41. doi: 10.1016/s0033-8338(07)73714-1.
8
The value of postlumpectomy mammogram in the management of breast cancer patients presenting with suspiciouis microcalcifications.保乳术后乳房X光检查在伴有可疑微钙化的乳腺癌患者管理中的价值。
Cancer J Sci Am. 2000 Jan-Feb;6(1):25-7.
9
Residual microcalcifications after neoadjuvant chemotherapy for locally advanced breast cancer: comparison of the accuracies of mammography and MRI in predicting pathological residual tumor.局部晚期乳腺癌新辅助化疗后残留微钙化：乳腺钼靶摄影与 MRI 预测病理残留肿瘤准确性的比较。
World J Surg Oncol. 2017 Nov 6;15(1):198. doi: 10.1186/s12957-017-1263-8.
10
Recurrence Yield of Stereotactic Biopsy of Suspicious Calcifications After Breast Conservation Therapy.保乳治疗后可疑钙化灶立体定向活检的复发率
Cureus. 2022 Apr 20;14(4):e24318. doi: 10.7759/cureus.24318. eCollection 2022 Apr.

引用本文的文献

1
Correlation of Mammographic Microcalcifications with Final Surgical Pathology After Neoadjuvant Chemotherapy for Breast Cancer.乳腺癌新辅助化疗后钼靶微钙化与最终外科病理的相关性。
Ann Surg Oncol. 2023 Jul;30(7):4123-4131. doi: 10.1245/s10434-023-13367-w. Epub 2023 Apr 8.
2
A Brief Review about the Role of Nanomaterials, Mineral-Organic Nanoparticles, and Extra-Bone Calcification in Promoting Carcinogenesis and Tumor Progression.关于纳米材料、矿物-有机纳米颗粒及骨外钙化在促进癌变和肿瘤进展中作用的简要综述
Biomedicines. 2019 Aug 28;7(3):65. doi: 10.3390/biomedicines7030065.

本文引用的文献

1
Histopathologic correlation of residual mammographic microcalcifications after neoadjuvant chemotherapy for locally advanced breast cancer.局部晚期乳腺癌新辅助化疗后残留乳腺钼靶微钙化的组织病理学相关性
Ann Surg Oncol. 2015 Apr;22(4):1111-7. doi: 10.1245/s10434-014-4113-8. Epub 2014 Oct 7.
2
The role of mammographic calcification in the neoadjuvant therapy of breast cancer imaging evaluation.乳腺钼靶钙化在乳腺癌新辅助治疗影像评估中的作用。
PLoS One. 2014 Feb 11;9(2):e88853. doi: 10.1371/journal.pone.0088853. eCollection 2014.
3
Pathologic Complete Response of HER-2 Neu-Positive Invasive Ductal Carcinoma and Ductal Carcinoma In Situ following Neoadjuvant Chemotherapy plus Trastuzumab: A Case Report and Review of Literature.
新辅助化疗联合曲妥珠单抗治疗后HER-2 Neu阳性浸润性导管癌及导管原位癌的病理完全缓解：1例报告并文献复习
Case Rep Surg. 2012;2012:454273. doi: 10.1155/2012/454273. Epub 2012 Jan 19.
4
Mammographic appearance of microcalcifications: can they change after neoadjuvant chemotherapy?
Breast J. 2006 Jan-Feb;12(1):86-7. doi: 10.1111/j.1075-122X.2006.00195.x.
5
Development of malignant breast microcalcifications after neoadjuvant chemotherapy in advanced breast cancer.晚期乳腺癌新辅助化疗后恶性乳腺微钙化的发生
Breast J. 2004 Mar-Apr;10(2):141-5. doi: 10.1111/j.1075-122x.2004.21365.x.
6
Locally advanced breast cancer: comparison of mammography, sonography and MR imaging in evaluation of residual disease in women receiving neoadjuvant chemotherapy.局部晚期乳腺癌：乳腺X线摄影、超声及磁共振成像在评估接受新辅助化疗女性残留病灶中的比较
Eur Radiol. 2004 Aug;14(8):1371-9. doi: 10.1007/s00330-004-2246-z. Epub 2004 Feb 18.
7
Primary breast cancer: mammographic changes after neoadjuvant chemotherapy, with pathologic correlation.
Radiology. 1996 Feb;198(2):333-40. doi: 10.1148/radiology.198.2.8596827.
8
Mammography in the assessment of response to medical treatment of large primary breast cancer.乳腺钼靶摄影在评估大型原发性乳腺癌药物治疗反应中的应用
Clin Radiol. 1993 May;47(5):339-44. doi: 10.1016/s0009-9260(05)81451-5.
9
Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy.
Radiology. 1988 Oct;169(1):49-54. doi: 10.1148/radiology.169.1.3420282.