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2
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Infect Immun. 1999 Jul;67(7):3610-8. doi: 10.1128/IAI.67.7.3610-3618.1999.

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Am J Pathol. 2010 Nov;177(5):2459-71. doi: 10.2353/ajpath.2010.100141. Epub 2010 Sep 23.
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Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis.肺结核患者细胞因子分泌差异及早期治疗反应
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I/St mice hypersusceptible to Mycobacterium tuberculosis are resistant to M. avium.对结核分枝杆菌高度敏感的I/St小鼠对鸟分枝杆菌具有抗性。
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本文引用的文献

1
CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis.CD40配体三聚体增强CD8⁺T细胞对结核分枝杆菌的反应。
J Immunol. 2003 Mar 15;170(6):3180-6. doi: 10.4049/jimmunol.170.6.3180.
2
Immunological basis of the development of necrotic lesions following Mycobacterium avium infection.鸟分枝杆菌感染后坏死性病变发生发展的免疫学基础。
Immunology. 2002 Aug;106(4):590-601. doi: 10.1046/j.1365-2567.2002.01459.x.
3
CD40 ligand (CD154) does not contribute to lymphocyte-mediated inhibition of virulent Mycobacterium tuberculosis within human monocytes.CD40配体（CD154）对人单核细胞内淋巴细胞介导的毒力结核分枝杆菌抑制作用无贡献。
Infect Immun. 2002 Aug;70(8):4716-20. doi: 10.1128/IAI.70.8.4716-4720.2002.
4
Hyper-IgM syndrome with systemic tuberculosis.伴有系统性结核病的高IgM综合征
Scand J Infect Dis. 2002;34(4):305-7. doi: 10.1080/00365540110080151.
5
CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide.CD40/CD40配体相互作用在宿主抵御播散性白色念珠菌感染中的作用：巨噬细胞衍生的一氧化氮的作用
Eur J Immunol. 2002 May;32(5):1455-63. doi: 10.1002/1521-4141(200205)32:5<1455::AID-IMMU1455>3.0.CO;2-C.
6
Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction.在缺乏CD40/CD154相互作用的情况下，曼氏血吸虫感染期间Th2细胞发育受损且死亡率增加。
J Immunol. 2002 May 1;168(9):4643-9. doi: 10.4049/jimmunol.168.9.4643.
7
Mycobacterium bovis BCG-induced granuloma formation depends on gamma interferon and CD40 ligand but does not require CD28.牛分枝杆菌卡介苗诱导的肉芽肿形成依赖于γ干扰素和CD40配体，但不需要CD28。
Infect Immun. 2001 Apr;69(4):2596-603. doi: 10.1128/IAI.69.4.2596-2603.2001.
8
A role for CD40-CD40 ligand interactions in the generation of type 1 cytokine responses in human leprosy.CD40-CD40配体相互作用在人类麻风病1型细胞因子应答产生中的作用。
J Immunol. 2000 Aug 1;165(3):1506-12. doi: 10.4049/jimmunol.165.3.1506.
9
Antigen specificity of T-cell response to Mycobacterium avium infection in mice.小鼠对鸟分枝杆菌感染的T细胞应答的抗原特异性
Infect Immun. 2000 Aug;68(8):4805-10. doi: 10.1128/IAI.68.8.4805-4810.2000.
10
Depressed CD40 ligand expression contributes to reduced gamma interferon production in human tuberculosis.CD40配体表达降低导致人类结核病中γ干扰素产生减少。
Infect Immun. 2000 May;68(5):3002-6. doi: 10.1128/IAI.68.5.3002-3006.2000.

CD40是对鸟分枝杆菌产生最佳保护性免疫诱导所必需的。

CD40 is required for the optimal induction of protective immunity to Mycobacterium avium.

作者信息

Flórido Manuela, Gonçalves Ana Sofia, Gomes M Salomé, Appelberg Rui

机构信息

Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.

出版信息

Immunology. 2004 Mar;111(3):323-7. doi: 10.1111/j.1365-2567.2004.01812.x.

DOI:10.1111/j.1365-2567.2004.01812.x
PMID:15009433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1782428/
Abstract

C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40-/-) mice than in control mice. The increased susceptibility to infection of CD40-/- mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages.

摘要

将C57Bl/6小鼠和缺乏CD40分子的小鼠用三株鸟分枝杆菌感染。其中两株鸟分枝杆菌在缺乏CD40（CD40-/-）的小鼠中比在对照小鼠中增殖更为广泛。与对照相比，CD40-/-小鼠对感染易感性增加与白细胞介素-12（IL-12）p40和干扰素-γ（IFN-γ）反应较差有关，提示CD40在保护性免疫的发展中起作用。相反，在受感染的巨噬细胞上直接激活CD40未能在受感染的巨噬细胞中诱导任何抗分枝杆菌活性。