CD40是对鸟分枝杆菌产生最佳保护性免疫诱导所必需的。
CD40 is required for the optimal induction of protective immunity to Mycobacterium avium.
作者信息
Flórido Manuela, Gonçalves Ana Sofia, Gomes M Salomé, Appelberg Rui
机构信息
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
出版信息
Immunology. 2004 Mar;111(3):323-7. doi: 10.1111/j.1365-2567.2004.01812.x.
Abstract
C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40-/-) mice than in control mice. The increased susceptibility to infection of CD40-/- mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages.
摘要
将C57Bl/6小鼠和缺乏CD40分子的小鼠用三株鸟分枝杆菌感染。其中两株鸟分枝杆菌在缺乏CD40（CD40-/-）的小鼠中比在对照小鼠中增殖更为广泛。与对照相比，CD40-/-小鼠对感染易感性增加与白细胞介素-12（IL-12）p40和干扰素-γ（IFN-γ）反应较差有关，提示CD40在保护性免疫的发展中起作用。相反，在受感染的巨噬细胞上直接激活CD40未能在受感染的巨噬细胞中诱导任何抗分枝杆菌活性。
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