双链RNA病毒。

The dsRNA viruses.

作者信息

Mertens Peter

机构信息

Institute for Animal Health, Pirbright Laboratories, Ash Road, Pirbright, Woking GU24 0NF, UK.

出版信息

Virus Res. 2004 Apr;101(1):3-13. doi: 10.1016/j.virusres.2003.12.002.

DOI:10.1016/j.virusres.2003.12.002

PMID:15010213

Abstract

The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes while avoiding the dsRNA activated defence mechanisms of their host species. These similarities appear to indicate a common if distant ancestry that is not always evident simply by comparison of nucleotide or amino acid sequences. To facilitate the identification and comparisons of cognate proteins from different species, genera and families of dsRNA viruses, a series of tables were originally constructed for the 7th International Symposium of dsRNA viruses held in Aruba in 2000. These have now been updated and extended (for the 8th Symposium, held in Tuscany 2003) and are available from the dsRNA virus website at.

摘要

双链RNA病毒是一大类多样的病原体（影响非常广泛的宿主物种），其中几种具有医学、兽医或农业重要性。许多二十面体双链RNA病毒表现出惊人的结构和功能相似性，这反映了它们在复制双链RNA基因组时面临的类似问题，同时还要避免宿主物种的双链RNA激活防御机制。这些相似性似乎表明它们有着共同的起源，即便关系较为疏远，这种起源并不总是能通过比较核苷酸或氨基酸序列轻易显现出来。为便于识别和比较来自双链RNA病毒不同物种、属和科的同源蛋白，最初为2000年在阿鲁巴举行的第七届双链RNA病毒国际研讨会构建了一系列表格。这些表格现已更新并扩充（用于2003年在托斯卡纳举行的第八届研讨会），可从双链RNA病毒网站获取。