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医院环境中的诺如病毒暴发:感染控制的作用

Norovirus outbreaks in a hospital setting: the role of infection control.

作者信息

Lynn Sarah, Toop Julianne, Hanger Carl, Millar Nigel

机构信息

Older Persons' Health, The Princess Margaret Hospital, Christchurch, New Zealand.

出版信息

N Z Med J. 2004 Feb 20;117(1189):U771.

Abstract

AIMS

Noroviruses (NV) (until recently known as Norwalk-like viruses) are a common cause of outbreaks of viral gastroenteritis and can result in significant hospital disruption. We report our experience of two outbreaks that occurred in a geriatric rehabilitation hospital and the role of infection control in limiting their spread.

METHODS

The outbreaks occurred in two separate rehabilitation wards for older people. A case definition was developed and a register kept to record patient and staff sickness. The NV was identified from faecal specimens by reverse transcriptase polymerase chain reaction.

RESULTS

There were 41 cases in the first outbreak, with an attack rate of 57.1% for patients and 41% for staff. The outbreak lasted 14 days and closed the ward for 11 days. During this outbreak one patient died, with gastroenteritis the precipitating event of his final illness. There were 24 cases in the second outbreak, with an attack rate of 56.5% for patients and 18% for staff. The outbreak lasted 16 days with the ward closed for six days. The mean duration of staff sickness was 3.5 days in the second outbreak compared with only 1.2 days in the first outbreak. In both outbreaks infection was contained within a single ward.

CONCLUSIONS

NV infections can significantly disrupt hospitals through their rapid spread to patients and staff as well as the associated high attack rate. Early recognition of an outbreak and prompt implementation of infection control measures, staffing restrictions and ward closure can limit the spread of infection.

摘要

目的

诺如病毒(NV)(直到最近还被称为诺沃克样病毒)是病毒性肠胃炎暴发的常见病因,可导致医院运营严重中断。我们报告了在一家老年康复医院发生的两起疫情以及感染控制在限制其传播方面所起的作用。

方法

疫情发生在两个独立的老年康复病房。制定了病例定义并进行登记,以记录患者和工作人员的患病情况。通过逆转录聚合酶链反应从粪便标本中鉴定出诺如病毒。

结果

第一次疫情中有41例病例,患者的感染率为57.1%,工作人员的感染率为41%。疫情持续了14天,病房关闭了11天。在此期间,一名患者死亡,肠胃炎是其最终病情的诱发事件。第二次疫情中有24例病例,患者的感染率为56.5%,工作人员的感染率为18%。疫情持续了16天,病房关闭了6天。第二次疫情中工作人员患病的平均持续时间为3.5天,而第一次疫情中仅为1.2天。在两起疫情中,感染都局限在一个病房内。

结论

诺如病毒感染可通过迅速传播给患者和工作人员以及相关的高感染率,对医院造成严重干扰。尽早识别疫情并迅速实施感染控制措施、人员限制和病房关闭,可限制感染的传播。

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