Masand Prakash S.
Department of Psychiatry, State University of New York Upstate Medical University, Syracuse.
Prim Care Companion J Clin Psychiatry. 2000 Jun;2(3):80-88. doi: 10.4088/pcc.v02n0302.
Behavioral disturbances and psychosis are common features of neurodegenerative disorders and may be drug induced, intrinsic to the underlying pathology, or both. These disturbances, including psychotic and mood symptoms, apathy, aggression and other behavioral symptoms, and superimposed delirium, cause a great amount of disability to the patient and stress on the caregiver. Conventional neuroleptics have been shown to be effective in the treatment of these symptoms, but unacceptable side effects may occur. However, the novel antipsychotics, with their lower risk of inducing extrapyramidal symptoms, have shown promise in the treatment of behavioral disturbances and psychosis associated with neurodegenerative disorders.
行为障碍和精神病是神经退行性疾病的常见特征，可能由药物引起，也可能是潜在病理所固有的，或者两者皆有。这些障碍包括精神病性和情绪症状、冷漠、攻击行为和其他行为症状，以及叠加的谵妄，给患者带来极大的残疾，并给照顾者带来压力。传统抗精神病药物已被证明对治疗这些症状有效，但可能会出现不可接受的副作用。然而，新型抗精神病药物诱发锥体外系症状的风险较低，在治疗与神经退行性疾病相关的行为障碍和精神病方面已显示出前景。
