使用舒必利和利培酮治疗亨廷顿病的对比试验：一项初步研究。

A comparative trial use of sulpiride and risperidone in Huntington's disease: a pilot study.

机构信息

Department of Psychiatry, Robert Kilpatrick Clinical Sciences Building, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK.

出版信息

J Psychopharmacol. 1996 Jan;10(2):162-5. doi: 10.1177/026988119601000213.

DOI:10.1177/026988119601000213

PMID:22302895

Abstract

Sulpiride and risperidone treatment significantly improved the abnormal involuntary movements of two patients with Huntington's disease on both actometer and clinical assessments. However, treatment with risperidone, but not sulpiride, significantly improved the functional activities as assessed by the Functional Disability Scale. To the best of our knowledge this is the first report of the successful treatment of Huntington's disease with risperidone.

摘要

舒必利和利培酮治疗显著改善了亨廷顿病患者的异常不自主运动，在动作计和临床评估上均有改善。然而，利培酮治疗而非舒必利治疗，显著改善了功能性残疾量表评估的功能性活动。据我们所知，这是首例使用利培酮成功治疗亨廷顿病的报告。