用于检测肾小球滤过率降低的尿胱抑素C与尿肌酐的比值。
The ratio of urinary cystatin C to urinary creatinine for detecting decreased GFR.
作者信息
Hellerstein Stanley, Berenbom Max, Erwin Pat, Wilson Nancy, DiMaggio Sylvia
机构信息
Section of Nephrology at The Children's Mercy Hospital, The University of Missouri School of Medicine at Kansas City, Kansas City, Missouri 64108, USA.
出版信息
Pediatr Nephrol. 2004 May;19(5):521-5. doi: 10.1007/s00467-003-1373-0. Epub 2004 Mar 10.
Glomerular filtration rate (GFR) and urine and serum concentrations of cystatin C and creatinine were measured in 40 boys and 42 girls. The fractional excretion of cystatin C (FE Cyst C) increased in proportion to the decrease in GFR. Since serum creatinine concentration (S-Creatinine) in the numerator of the fractional excretion equation and serum cystatin C concentration (S-Cystatin C) in the denominator have similar numerical values, they cancel out. The result is an equation in which the FE Cyst C is equal to the ratio of urinary cystatin C to urinary creatinine (u[cystatin-C/Cr]). The ratio of u[cystatin C/Cr] was compared with GFR. Using a receiving operating characteristic (ROC) plot, the data showed that a ratio of u[cystatin C/Cr]*100 that is > or =0.100 has a sensitivity of 90.0% for identification of children with GFR < or =60 ml/min per 1.73 m(2). The false-positive rate is 16.1%. The u[cystatin C/Cr] ratio is a reliable screening tool for detecting decreased GFR that does not require a serum sample.
对40名男孩和42名女孩测量了肾小球滤过率（GFR）以及胱抑素C和肌酐的尿液及血清浓度。胱抑素C的分数排泄率（FE Cyst C）随GFR的降低成比例增加。由于分数排泄方程分子中的血清肌酐浓度（S - 肌酐）与分母中的血清胱抑素C浓度（S - 胱抑素C）数值相似，它们相互抵消。结果得到一个方程，其中FE Cyst C等于尿胱抑素C与尿肌酐的比值（u[胱抑素 - C/Cr]）。将u[胱抑素C/Cr]比值与GFR进行比较。使用受试者工作特征（ROC）曲线，数据显示u[胱抑素C/Cr]×100≥0.100时，识别GFR≤60 ml/（min·1.73 m²）儿童的灵敏度为90.0%。假阳性率为16.1%。u[胱抑素C/Cr]比值是一种可靠的筛查工具，用于检测GFR降低，且无需采集血清样本。
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