Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Brodehl J
Children's Hospital, Hannover Medical School, Germany.
Pediatr Nephrol. 1998 Feb;12(2):125-9. doi: 10.1007/s004670050419.
Cystatin C, a low molecular weight protein, is a new endogenous marker of renal function whose serum concentration correlates better with glomerular filtration rate than creatinine. The aim of the present study was to define a reference interval for cystatin C concentrations in children. Cystatin C was measured by an immunoturbidimetric assay in sera obtained from 258 children (93 girls, 165 boys, median age 6.29 years, range 1 day to 18 years) without evidence of kidney disease. The reference interval was calculated non-parametrically using the 2.5th and 97.5th percentiles. For comparison, creatinine was measured in the same samples. The cystatin C concentration was highest on the first days of life (range 1.64-2.59 mg/l) with a rapid decrease during the first 4 months. Beyond the 1st year, the cystatin C concentration was constant, with a reference interval of 0.7-1.38 mg/l. In contrast, serum creatinine concentrations steadily increased with age until adulthood. Compared with creatinine, cystatin C facilitates the recognition of abnormal renal function in children as its reference range is constant beyond the 1st year of life. The higher levels of cystatin C in the 1st year of life probably reflect the low glomerular filtration rate of neonates and infants.
胱抑素C是一种低分子量蛋白质，是一种新的肾功能内源性标志物，其血清浓度与肾小球滤过率的相关性比肌酐更好。本研究的目的是确定儿童胱抑素C浓度的参考区间。采用免疫比浊法测定了258名无肾脏疾病证据的儿童（93名女孩，165名男孩，中位年龄6.29岁，范围1天至18岁）血清中的胱抑素C。使用第2.5百分位数和第97.5百分位数非参数计算参考区间。为作比较，在相同样本中测定肌酐。胱抑素C浓度在出生后的头几天最高（范围为1.64 - 2.59mg/l），在头4个月内迅速下降。1岁以后，胱抑素C浓度保持恒定，参考区间为0.7 - 1.38mg/l。相比之下，血清肌酐浓度随年龄稳步增加直至成年。与肌酐相比，胱抑素C有助于识别儿童的肾功能异常，因为其参考范围在1岁以后保持恒定。出生后第1年胱抑素C水平较高可能反映了新生儿和婴儿的肾小球滤过率较低。
