Pan Rui-le, Chen Di-hua, Si Jian-yong, Zhao Xiao-hong, Shen Lian-gang
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
Zhongguo Zhong Yao Za Zhi. 2003 Mar;28(3):230-2.
To find new active constituents from the aerial part of Cimicifuga foetida.
Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences.
Four 9,19-cycloartane triterpenoid saponins were obtained and identified as Cimifoetiside III (25-anhydrocimigenol-3-O-beta-D-galactopyranoside, 1), 25-O-acetyl-cimigenol xylopyranoside (2), 25-O-acetyl-cimigenol galactopyranoside (3), 7 beta-hydrocimigenol xylopyranoside (4).
Compound 1 is new and compound 4 was isolated from this plant for the first time.
从升麻地上部分寻找新的活性成分。
采用多种柱色谱技术对化合物进行分离纯化。通过光谱数据和化学证据阐明其结构。
得到4个9,19-环阿尔廷烷型三萜皂苷，分别鉴定为升麻苷III（25-脱水升麻醇-3-O-β-D-吡喃半乳糖苷，1）、25-O-乙酰基升麻醇吡喃木糖苷（2）、25-O-乙酰基升麻醇吡喃半乳糖苷（3）、7β-羟基升麻醇吡喃木糖苷（4）。
化合物1为新化合物，化合物4首次从该植物中分离得到。
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