Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90025, USA; Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Key Laboratory of Chinese Materia Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Chin J Nat Med. 2016 Oct;14(10):721-731. doi: 10.1016/S1875-5364(16)30087-5. Epub 2016 Oct 31.
The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9, 19-cyclolanostane triterpenoid glycosides, which often exhibit extensive pharmacological activities. 9, 19-Cyclolanostane triterpenoid glycosides are distributed widely in genus Cimicifuga rather than in other members of the Ranunculaceae family. So far, more than 140 cycloartane triterpene glycosides have been isolated from Cimicifuga spp.. The aim of this review was to summarize all 9, 19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.
升麻属植物的成分已被广泛研究,其主要代谢产物为 9,19-环羊毛甾烷型三萜糖苷,通常具有广泛的药理活性。9,19-环羊毛甾烷型三萜糖苷广泛分布于升麻属,而不是毛茛科的其他成员中。到目前为止,已经从升麻属中分离出 140 多种环阿尔廷三萜糖苷。本综述的目的是根据 2000 年至 2014 年的相关科学文献,总结所有的 9,19-环羊毛甾烷型三萜糖苷。还讨论了升麻属中环阿尔廷三萜糖苷的生物学研究。