Al-Khan Anthony, Jones Roger, Fricchione Donald, Apuzzio Joseph
Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, and Columbus Hospital, Newark, New Jersey 07101-1709, USA.
J Reprod Med. 2004 Feb;49(2):121-2.
Ectopic pregnancy is the leading cause of first-trimester maternal death, accounting for 9% of pregnancy-related deaths. Interstitial (cornual) pregnancies represent 6% of all ectopics but account for a disproportionately higher mortality rate. Surgical management has been the treatment of choice for interstitial pregnancies. A very limited number of articles pre have explored the use of intravenous methotrexate to treat cornual pregnancy as a possible conservative first-line therapy in selected, hemodynamically stable patients.
A patient with a confirmed interstitial pregnancy was treated with intravenous methotrexate. The patient's beta-hCG levels decreased to zero within 9 weeks.
Intravenous methotrexate was used successfully in the treatment of an interstitial pregnancy without complications.
异位妊娠是孕早期孕产妇死亡的主要原因，占与妊娠相关死亡的9%。间质部（宫角部）妊娠占所有异位妊娠的6%，但其死亡率却高得不成比例。手术治疗一直是间质部妊娠的首选治疗方法。此前仅有极少数文章探讨了在选定的血流动力学稳定的患者中使用静脉注射甲氨蝶呤作为可能的保守一线疗法来治疗宫角妊娠。
一名确诊为间质部妊娠的患者接受了静脉注射甲氨蝶呤治疗。患者的β - 人绒毛膜促性腺激素水平在9周内降至零。
静脉注射甲氨蝶呤成功用于间质部妊娠的治疗，且无并发症。
