Fearon Kenneth C H, Luff Rachel
Department of Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Room F3307, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 45A, UK.
Proc Nutr Soc. 2003 Nov;62(4):807-11. doi: 10.1079/PNS2003299.
Malnutrition has long been recognised as a risk factor for post-operative morbidity and mortality. Traditional metabolic and nutritional care of patients undergoing major elective surgery has emphasised pre-operative fasting and re-introduction of oral nutrition 3-5 d after surgery. Attempts to attenuate the consequent nutritional deficit and to influence post-operative morbidity and mortality have included parenteral, enteral and oral sip feeding. Recent studies have emphasised that an enhanced rate of recovery can be achieved by a multi-modal approach focused on modulating the metabolic status of the patient before (e.g. carbohydrate and fluid loading), during (e.g. epidural anaesthesia) and after (e.g. early oral feeding) surgery. Using such an approach preliminary results on patients undergoing elective colo-rectal surgery indicate a significant reduction in hospital stay (traditional care, n 48, median stay 10 d v. enhanced recovery programme, n 33, median stay 7d; P<0.01) can be achieved. Such findings emphasise the potential role of multi-modal care programmes in the promotion of early recovery from major surgical trauma.
长期以来,营养不良一直被视为术后发病和死亡的危险因素。对接受大型择期手术患者的传统代谢和营养护理一直强调术前禁食,并在术后3至5天重新引入口服营养。减轻由此产生的营养不足并影响术后发病和死亡的尝试包括肠外营养、肠内营养和口服少量进食。最近的研究强调,通过多模式方法可以提高恢复速度,该方法侧重于在手术前(如碳水化合物和液体负荷)、手术期间(如硬膜外麻醉)和手术后(如早期口服喂养)调节患者的代谢状态。对接受择期结直肠手术的患者采用这种方法的初步结果表明,住院时间可显著缩短(传统护理组,n = 48,中位住院时间10天;强化恢复计划组,n = 33,中位住院时间7天;P<0.01)。这些发现强调了多模式护理计划在促进从重大手术创伤中早期恢复方面的潜在作用。