秀丽隐杆线虫化学感受神经元亚型身份的特异性

Specification of chemosensory neuron subtype identities in Caenorhabditis elegans.

作者信息

Lanjuin Anne, Sengupta Piali

机构信息

Department of Biology, Brandeis University, MS008, 415 South Street, Waltham, MA 02454, USA.

出版信息

Curr Opin Neurobiol. 2004 Feb;14(1):22-30. doi: 10.1016/j.conb.2004.01.006.

DOI:10.1016/j.conb.2004.01.006

PMID:15018934

Abstract

Cellular diversity in the nervous system arises from the presence of multiple neuronal subtypes, each of which is specialized to perform a unique function. Work in Caenorhabditis elegans has begun to reveal the pathways that are essential for the specification of identities of neuronal subtypes in its chemosensory system. The functions of each chemosensory neuron subtype are specified by distinct developmental cascades, using molecules from well-conserved transcription factor families. Additional cellular complexity is generated by novel mechanisms that further diversify the identities of the left and right members of a bilateral sensory neuron pair.

摘要

神经系统中的细胞多样性源于多种神经元亚型的存在，每种亚型都专门执行独特的功能。秀丽隐杆线虫的研究已开始揭示其化学感受系统中神经元亚型身份特化所必需的信号通路。每个化学感受神经元亚型的功能由不同的发育级联决定，这些级联使用来自保守转录因子家族的分子。新机制进一步增加了细胞复杂性，使双侧感觉神经元对的左右成员身份更加多样化。