• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

作者信息

O'Donnell James M, Zhang Han-Ting

机构信息

Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

出版信息

Trends Pharmacol Sci. 2004 Mar;25(3):158-63. doi: 10.1016/j.tips.2004.01.003.

DOI:10.1016/j.tips.2004.01.003
PMID:15019272
Abstract
摘要

相似文献

1
Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).环磷酸腺苷磷酸二酯酶4(PDE4)抑制剂的抗抑郁作用
Trends Pharmacol Sci. 2004 Mar;25(3):158-63. doi: 10.1016/j.tips.2004.01.003.
2
The potential of phosphodiesterase 4 inhibitors for the treatment of depression: opportunities and challenges.磷酸二酯酶4抑制剂治疗抑郁症的潜力:机遇与挑战。
Curr Opin Investig Drugs. 2004 Jan;5(1):34-9.
3
Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding.选择性磷酸二酯酶4(PDE4)抑制剂的行为效应与催化活性抑制及对[3H]咯利普兰结合的竞争关系
Neurobiology (Bp). 1999;7(1):71-3.
4
Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats.磷酸二酯酶-4(PDE4)的高亲和力咯利普兰结合状态(HARBS)介导的PDE4抑制剂在大鼠中的抗抑郁样作用。
Psychopharmacology (Berl). 2006 Jun;186(2):209-17. doi: 10.1007/s00213-006-0369-4. Epub 2006 Apr 4.
5
Implications of PDE4 structure on inhibitor selectivity across PDE families.磷酸二酯酶4(PDE4)结构对跨磷酸二酯酶家族抑制剂选择性的影响。
Int J Impot Res. 2004 Jun;16 Suppl 1:S24-7. doi: 10.1038/sj.ijir.3901211.
6
Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries.3型和4型磷酸二酯酶抑制剂对脑动脉作用的分析。
Eur J Pharmacol. 2004 Apr 5;489(1-2):93-100. doi: 10.1016/j.ejphar.2004.02.038.
7
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation.4型环磷酸腺苷磷酸二酯酶(PDE4)抑制剂在无外源性腺苷酸环化酶刺激的情况下,增强糖皮质激素介导的B细胞慢性淋巴细胞白血病(B-CLL)细胞凋亡。
Biochem Pharmacol. 2005 Feb 1;69(3):473-83. doi: 10.1016/j.bcp.2004.10.009. Epub 2004 Dec 15.
8
Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents.磷酸二酯酶4抑制剂作为新型抗炎药。
Curr Opin Chem Biol. 1999 Aug;3(4):466-73. doi: 10.1016/S1367-5931(99)80068-4.
9
Phosphodiesterase inhibitors in airways disease.气道疾病中的磷酸二酯酶抑制剂
Eur J Pharmacol. 2006 Mar 8;533(1-3):110-7. doi: 10.1016/j.ejphar.2005.12.059. Epub 2006 Feb 2.
10
Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors.新一代磷酸二酯酶4抑制剂对人子宫肌层的抗炎及子宫舒张作用
Biol Reprod. 2004 Feb;70(2):458-64. doi: 10.1095/biolreprod.103.023051. Epub 2003 Oct 15.

引用本文的文献

1
Rafting toward a depression biomarker.探寻抑郁症生物标志物
Eur Arch Psychiatry Clin Neurosci. 2025 Aug 19. doi: 10.1007/s00406-025-02071-3.
2
A heterotrimeric G protein (Gsα) biomarker may predict antidepressant response in subjects with major depressive disorder.一种异源三聚体G蛋白(Gsα)生物标志物可能预测重度抑郁症患者的抗抑郁反应。
Front Psychiatry. 2025 Jul 18;16:1619243. doi: 10.3389/fpsyt.2025.1619243. eCollection 2025.
3
Less is more: calorie restriction as a therapeutic for mental health disorders.少即是多:热量限制作为一种治疗精神疾病的方法。
Front Psychiatry. 2025 Jun 16;16:1584890. doi: 10.3389/fpsyt.2025.1584890. eCollection 2025.
4
A simple platelet biomarker is associated with symptom severity in major depressive disorder.一种简单的血小板生物标志物与重度抑郁症的症状严重程度相关。
Mol Psychiatry. 2025 Mar 4. doi: 10.1038/s41380-025-02941-1.
5
Phosphodiesterase 4 Inhibition in Neuropsychiatric Disorders Associated with Alzheimer's Disease.磷酸二酯酶4抑制在与阿尔茨海默病相关的神经精神疾病中的作用
Cells. 2025 Jan 22;14(3):164. doi: 10.3390/cells14030164.
6
Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3xTg-AD mice via PDE4B/cAMP/PKA signaling.抑制磷酸二酯酶4B(PDE4B)可通过PDE4B/环磷酸腺苷(cAMP)/蛋白激酶A(PKA)信号通路改善3xTg-AD小鼠酒精性痴呆模型中的认知缺陷。
Int J Neuropsychopharmacol. 2025 Mar 20;28(3). doi: 10.1093/ijnp/pyaf009.
7
Advances in pyrazolo[1,5-]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment.吡唑并[1,5 - ]嘧啶的研究进展:合成及其在癌症治疗中作为蛋白激酶抑制剂的作用
RSC Adv. 2025 Feb 5;15(5):3756-3828. doi: 10.1039/d4ra07556k. eCollection 2025 Jan 29.
8
Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management.姜黄素与癌症和炎症:分子相互作用、治疗潜力及在疾病管理中的作用的深入探讨
Int J Mol Sci. 2024 Mar 2;25(5):2911. doi: 10.3390/ijms25052911.
9
A study of roflumilast treatment on functional and structural changes in hippocampus in depressed Adult male Wistar rats.罗氟司特治疗成年雄性Wistar抑郁大鼠海马功能和结构变化的研究
PLoS One. 2024 Feb 5;19(2):e0296187. doi: 10.1371/journal.pone.0296187. eCollection 2024.
10
Gα, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression.Gα、腺苷酸环化酶及其与抑郁症诊断和治疗的关系。
Front Pharmacol. 2022 Nov 18;13:1012778. doi: 10.3389/fphar.2022.1012778. eCollection 2022.