Rasenick Mark M
Psychiatry and Physiology, University ofIllinois College of Medicine, Jesse Brown VAMC, Chicago, IL, 60612, USA.
Eur Arch Psychiatry Clin Neurosci. 2025 Aug 19. doi: 10.1007/s00406-025-02071-3.
The journey from the cytoskeleton and G protein signaling to a framework that might provide a simple blood diagnostic for depression as well as a harbinger of individual antidepressant response, has been convoluted, occasionally frustrating, but ultimately rewarding. Herein, I provide a travelogue of sorts on our progress toward this end, and also chart a course toward the goal of providing a simple, quantitative and objective, biomarker-driven assessment tool that reflects the neurobiology of depressed mood.
从细胞骨架和G蛋白信号传导到一个可能为抑郁症提供简单血液诊断以及个体抗抑郁反应先兆的框架，这一旅程错综复杂，有时令人沮丧，但最终收获颇丰。在此，我提供一份关于我们朝着这个目标取得的进展的某种旅行记录，并规划一条朝着提供一种简单、定量且客观的、由生物标志物驱动的评估工具的目标前进的路线，该工具能反映抑郁情绪的神经生物学特征。
