Tveit Arnljot, Grundtvig Morten, Gundersen Torstein, Vanberg Paul, Semb Anne Grete, Holt Even, Gullestad Lars
Department of Internal Medicine, Asker & Baerum Hospital, Rud, Norway.
Am J Cardiol. 2004 Mar 15;93(6):780-2. doi: 10.1016/j.amjcard.2003.12.009.
To test the hypothesis that a statin could reduce the recurrence rate of atrial fibrillation after electrical cardioversion (EC), we performed an open, controlled multicenter study. Patients (n = 114) who had atrial fibrillation >48 hours and who were scheduled for EC were randomized to receive 40 mg of pravastatin once daily for 3 weeks before and 6 weeks after EC or no drug in addition to standard therapy. Pravastatin did not reduce the recurrence rate of atrial fibrillation after EC.
为了验证他汀类药物可降低电复律（EC）后房颤复发率这一假设，我们开展了一项开放性、对照多中心研究。入选的房颤持续时间超过48小时且计划接受电复律的患者（n = 114）被随机分为两组，一组在电复律前3周及电复律后6周每天服用40 mg普伐他汀，另一组除标准治疗外不服用任何药物。普伐他汀未能降低电复律后房颤的复发率。
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