Bowen Nathan J, Fujita Naoyuki, Kajita Masahiro, Wade Paul A
Department of Genetics, University of Georgia, Athens, GA, USA.
Biochim Biophys Acta. 2004 Mar 15;1677(1-3):52-7. doi: 10.1016/j.bbaexp.2003.10.010.
The vertebrate Mi-2/NuRD complex is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Surprisingly, every subunit of this complex presents heterogeneity at the protein and gene level. This raises the intriguing possibility of functional specialization resulting from incorporation of unique gene products into the complex. The MTA (metastasis-associated) proteins represent one class of alternative subunits of the human Mi-2/NuRD complex. The members of this family in human cells are differentially expressed depending on cell type and on physiologic parameters. We summarize evidence supporting the view that the alternative subunits of the complex that have arisen during vertebrate evolution endow unique functional properties.
脊椎动物的Mi-2/NuRD复合物是一种多亚基蛋白质复合物，包含组蛋白脱乙酰酶和核小体依赖性ATP酶亚基。目前的模型预测，该复合物主要在转录抑制中发挥作用。令人惊讶的是，该复合物的每个亚基在蛋白质和基因水平上都呈现出异质性。这就引发了一种有趣的可能性，即独特的基因产物整合到复合物中导致功能特化。MTA（转移相关）蛋白是人类Mi-2/NuRD复合物的一类替代亚基。该家族成员在人类细胞中的表达因细胞类型和生理参数而异。我们总结了支持以下观点的证据：在脊椎动物进化过程中出现的复合物替代亚基赋予了独特的功能特性。
