Denslow S A, Wade P A
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Oncogene. 2007 Aug 13;26(37):5433-8. doi: 10.1038/sj.onc.1210611.
The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity.
Mi-2/核小体重塑与去乙酰化酶（NuRD）复合物是一种丰富的去乙酰化酶复合物，在细胞和组织中广泛分布。它的独特之处在于，它在同一复合物中耦合了组蛋白去乙酰化和染色质重塑ATP酶活性。十年的研究揭示了Mi-2/NuRD与基因调控之间的一些有趣联系。该酶的亚基组成似乎随细胞类型以及组织内生理信号的变化而变化。在这里，我们综述了该复合物的已知亚基、它们与信号网络的联系以及它们与癌症的关联。此外，我们提出了一个工作模型，该模型将该酶的已知生化特性与关于染色质结构和修饰如何与基因活性相关的新兴模型整合在一起。
