Palaszynski Karen M, Liu Hongbiao, Loo Kyi Kyi, Voskuhl Rhonda R
Department of Neurology, Reed Neurological Research Center, University of California School of Medicine, 750 Westwood Plaza, Los Angeles, CA 90095, USA.
J Neuroimmunol. 2004 Apr;149(1-2):84-9. doi: 10.1016/j.jneuroim.2003.12.015.
Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERalpha and ERbeta, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.
雌激素治疗已被发现在实验性自身免疫性脑脊髓炎（EAE）以及可能的多发性硬化症（MS）中具有保护作用。我们研究了雌激素治疗的效果是否具有性别特异性。雌激素受体（ER）的表达，即ERα和ERβ，在两性中被发现是相当的。与安慰剂相比，雌三醇治疗使雌性和雄性的EAE疾病严重程度均降低。最后，雌三醇治疗使雌性和雄性在自身抗原特异性免疫反应期间促炎细胞因子的产生均减少。这些数据支持了雌三醇治疗对患有MS的男性以及女性均具有潜在作用。
