透明质酸浓度对壳聚糖-明胶-透明质酸（Cs-Gel-HA）膜性能及生物相容性的影响。
Influence of the concentrations of hyaluronic acid on the properties and biocompatibility of Cs-Gel-HA membranes.
作者信息
Liu Haifeng, Yin Yuji, Yao Kangde, Ma Dongrui, Cui Lei, Cao Yilin
机构信息
Research Institute of Polymer Materials, Tianjin University, Tianjin 300072, People's Republic of China.
出版信息
Biomaterials. 2004 Aug;25(17):3523-30. doi: 10.1016/j.biomaterials.2003.09.102.
The object of this study was to investigate the relationship between the concentrations of HA solutions and the physicochemical properties and the biocompatibility of Cs-Gel-HA membranes. The addition of different concentrations of HA not only improved the wettability significantly and extended the degradation time of Cs-Gel-HA membranes, but also changed their mechanical properties. The concentration of HA had a significant influence on the biocompatibility of Cs-Gel-HA membranes. Results demonstrated that it was only the concentrations of HA in a certain range (0.01-0.1%), that could promote the cell adhesion, migration and proliferation, while the concentration of HA was above 0.1% it would either reduce or even inhibit these behaviors.
本研究的目的是探讨透明质酸（HA）溶液浓度与Cs-Gel-HA膜的物理化学性质及生物相容性之间的关系。添加不同浓度的HA不仅显著提高了Cs-Gel-HA膜的润湿性并延长了其降解时间，还改变了它们的机械性能。HA的浓度对Cs-Gel-HA膜的生物相容性有显著影响。结果表明，只有在一定范围内（0.01-0.1%）的HA浓度才能促进细胞的黏附、迁移和增殖，而当HA浓度高于0.1%时，它会降低甚至抑制这些行为。
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