Talebi Ardakani Mohammadreza, Moscowchi Anahita, Talebi Amir, Talebi Mohammad Hossein
Dental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 1983963113, Daneshjoo Blvd., Evin, Shahid Chamran Highway, Tehran, Iran.
Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Oral Health. 2025 Jan 22;25(1):119. doi: 10.1186/s12903-025-05526-0.
Treatment of gingival recessions through surgical approaches is a common periodontal intervention. There is a rise in using biologics in root coverage procedures. As it has been shown that hyaluronic acid (HA) promotes wound healing, this review aimed to assess its efficacy in the treatment of gingival recessions.
An electronic search was conducted across several databases (Medline/ PubMed, Embase, Scopus, Web of Science) supplemented by manual searching. The effectiveness of using HA was evaluated using various outcome measures, with the primary indicators being complete and mean coverage, recession depth, and recession width. Meta-analysis was performed to estimate the differences between test and control sites.
A total of 9 studies were eligible for inclusion. The overall analysis showed no significant difference between coronally advanced flap (CAF) + HA and control groups (CAF alone or CAF + sub-epithelial connective tissue graft) in terms of mean root coverage with a mean difference of 8.23 (95% confidence interval -3.06 to 19.53) and p = 0.12.
The current evidence suggests that the local application of HA may have some slight benefits over CAF alone in certain parameters. Nevertheless, its application does not add significant benefits to connective tissue graft. Given the high heterogeneity among the studies, further research with extended follow-up periods is necessary to better understand the clinical implications of using hyaluronic acid in this context.
CRD42024580649.
通过手术方法治疗牙龈退缩是一种常见的牙周干预措施。在牙根覆盖手术中使用生物制剂的情况有所增加。由于已表明透明质酸（HA）可促进伤口愈合，本综述旨在评估其在治疗牙龈退缩中的疗效。
在多个数据库（Medline/ PubMed、Embase、Scopus、Web of Science）中进行电子检索，并辅以手动检索。使用各种结局指标评估使用HA的有效性，主要指标为完全覆盖和平均覆盖、退缩深度和退缩宽度。进行荟萃分析以估计试验组和对照组之间的差异。
共有9项研究符合纳入标准。总体分析显示，在平均牙根覆盖方面，冠向推进瓣（CAF）+ HA组与对照组（单独使用CAF或CAF + 上皮下结缔组织移植）之间无显著差异，平均差异为8.23（95%置信区间 -3.06至19.53），p = 0.12。
目前的证据表明，在某些参数方面，局部应用HA可能比单独使用CAF有一些轻微益处。然而，其应用并未给结缔组织移植带来显著益处。鉴于研究之间存在高度异质性，有必要进行更长随访期的进一步研究，以更好地了解在此背景下使用透明质酸的临床意义。
CRD42024580649。
