Cho Hanjin, Chung Dongjun, Jeongho An
Department of Polymer Science and Engineering, Center for Advanced Functional Polymers, Sungkyunkwan University, Suwon 440-746, South Korea.
Biomaterials. 2004 Aug;25(17):3733-42. doi: 10.1016/j.biomaterials.2003.09.106.
P(DLAX-ran-CLY)n-b-PEG-b-P(DLAX-ran-CLY)ns (P(DLAX-ran-CLY)m: Poly(d,l-lactide-ran-epsilon-caprolactone), PEG: Poly(ethylene glycol), X: d,l-lactyl unit ratio, Y: epsilon-caproyl unit ratio, m : molecular weight of P(DLAX-ran-CLY)), were investigated as the novel parenteral drug-delivery system. The thermal behavior in the DSC characterization and variable viscosity with temperature suggest their potential usuage as a injectable drug-delivery system. The variation of tri-block structure affects the drug release behavior by changing the morphology and also by changing the interaction between the polymer matrix and the hydrophilic drug.
