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可生物降解的聚（ε-己内酯）-聚（乙二醇）共聚物作为药物传递系统。

Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system.

机构信息

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Int J Pharm. 2009 Oct 20;381(1):1-18. doi: 10.1016/j.ijpharm.2009.07.033. Epub 2009 Aug 5.

DOI:10.1016/j.ijpharm.2009.07.033
PMID:19664700
Abstract

Poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and medicinal chemistry. This review introduced several aspects of PCL-PEG copolymers, including synthetic chemistry, PCL-PEG micro/nanoparticles, PCL-PEG hydrogels, and physicochemical and toxicological properties.

摘要

聚（ε-己内酯）-聚（乙二醇）（PCL-PEG）共聚物是具有两亲性、可控生物降解性和良好生物相容性的重要合成生物医学材料。它们在纳米技术、组织工程、药物制剂和药物化学等领域具有巨大的潜在应用价值。本综述介绍了 PCL-PEG 共聚物的几个方面，包括合成化学、PCL-PEG 微/纳米粒子、PCL-PEG 水凝胶以及物理化学和毒理学性质。

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