Delhomme-Bachy M, Bertheas M F, Vasselon C, Calmard-Oriol P, Jaubert J, Rimokh R, Brizard C P, Guyotat D
Département d'Hématologie, Hôpital Nord, St Priest en Jarez, France.
Nouv Rev Fr Hematol (1978). 1992;34(2):175-82.
The chromosome constitutions of stimulated lymphocytes from 50 B-cell chronic lymphocytic leukemia patients were studied using different stimulation systems, i.e., TPA alone or associated with different cytokines. Adequate metaphases were obtained in 44 subjects (88%). Among 20 patients with abnormal karyotypes (45.5%), 7 had trisomy 12. The most frequent structural abnormality was a 14q+ resulting from translocations including one t(11;14) and two t(14;17), while deletions on the long arms of chromosomes 6 and 13 constituted a second common alteration. The most important finding in this series was the recurrence of a t(18;22) observed in two cases.
使用不同的刺激系统，即单独使用佛波酯（TPA）或与不同细胞因子联合使用，研究了50例B细胞慢性淋巴细胞白血病患者刺激淋巴细胞的染色体组成。44例受试者（88%）获得了足够的中期分裂相。在20例核型异常的患者中（45.5%），7例有12号染色体三体。最常见的结构异常是14q+，由易位导致，包括1例t(11;14)和2例t(14;17)，而6号和13号染色体长臂的缺失构成了第二种常见改变。该系列中最重要的发现是在2例患者中观察到t(18;22)的复发。
