Gahrton G, Juliusson G
Department of Medicine, Karolinska Institute, Huddinge, Sweden.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):389-92.
Chromosome analysis was made on mitogen-activated leukemic cells from 99 patients with B-cell chronic lymphocytic leukaemia. Fifty-three patients had clonal chromosome aberrations. Nine patients had trisomy 12 as the sole abnormality, 15 had trisomy, 12 together with other chromosomal aberrations, and 29 had other clonal abnormalities. Four patients had t(11;14), whereas 6 had 14q+ and five 11q- as the result of other translocations than t(11;14). Structural aberrations involving chromosomes 6, 12, and 13 were involved in 7, 4, and 5 patients, respectively. Patients with clonal aberrations had poor survival compared to those with normal karyotype, and patients with single trisomy 12 had poor survival as compared to patients with other single aberrations.
对99例B细胞慢性淋巴细胞白血病患者经丝裂原激活的白血病细胞进行了染色体分析。53例患者存在克隆性染色体畸变。9例患者仅有12号染色体三体这一异常，15例患者有12号染色体三体以及其他染色体畸变，29例患者有其他克隆性异常。4例患者存在t(11;14)，而6例患者因t(11;14)以外的其他易位出现14q+，5例患者出现11q-。涉及6号、12号和13号染色体的结构畸变分别出现在7例、4例和5例患者中。与核型正常的患者相比，有克隆性畸变的患者生存率较低，与有其他单一畸变的患者相比，仅有1号染色体三体的患者生存率较低。
