用于催化不对称转化的新型双酚基、可微调的单齿亚磷酰胺配体。
New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations.
作者信息
Hua Zihao, Vassar Victor C, Choi Hojae, Ojima Iwao
机构信息
Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5411-6. doi: 10.1073/pnas.0307101101. Epub 2004 Mar 12.
Abstract
Monodentate phosphoramidite ligands have been developed based on enantiopure 6,6'-dimethylbiphenols with axial chirality. These chiral ligands are easy to prepare and flexible for modifications. The fine-tuning capability of these ligands plays a significant role in achieving high enantioselectivity in the asymmetric hydroformylation of allyl cyanide and the conjugate addition of diethylzinc to cycloalkenones.
摘要
基于具有轴手性的对映体纯6,6'-二甲基联苯酚，开发了单齿亚磷酰胺配体。这些手性配体易于制备且修饰灵活。这些配体的微调能力在烯丙基氰的不对称氢甲酰化反应以及二乙基锌与环烯酮的共轭加成反应中实现高对映选择性方面发挥了重要作用。
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