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尤因肉瘤切除术后髋臼骨关节异体移植

Acetabular osteoarticular allograft after Ewing's sarcoma resection.

作者信息

Verma Nikil N, Kuo Ken N, Gitelis Steven

机构信息

Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA.

出版信息

Clin Orthop Relat Res. 2004 Feb(419):149-54. doi: 10.1097/00003086-200402000-00024.

Abstract

Ewing's sarcoma of the pelvis traditionally has been a difficult problem in orthopaedic oncology. Multiple studies have had inferior outcomes when compared with outcomes of patients with similar stage disease involving only the extremities. A major reason for this discrepancy is the difficulty associated with resection and reconstruction of pelvic tumors. Often the tumors are deemed nonresectable and are treated with chemotherapy and radiation or radiation alone. Patients treated in this manner have lower 5-year survival rates, higher local recurrence rates, and multiple long-term complications. The case of a 4-year-old girl with Ewing's sarcoma of the left hemi-pelvis is reported. Combined with adjuvant chemotherapy, this patient was treated with resection followed by osteoarticular allograft reconstruction. At 2 years followup, the patient was disease-free with an excellent functional outcome.

摘要

骨盆尤因肉瘤在传统上一直是骨肿瘤学中的难题。与仅累及四肢的相似分期疾病患者的治疗结果相比,多项研究的结果较差。这种差异的一个主要原因是骨盆肿瘤的切除和重建存在困难。通常这些肿瘤被认为无法切除,仅接受化疗和放疗或单纯放疗。以这种方式治疗的患者5年生存率较低,局部复发率较高,且有多种长期并发症。本文报道了一名4岁左侧半骨盆尤因肉瘤女童的病例。该患者在辅助化疗的基础上,接受了切除手术,随后进行了骨关节异体移植重建。随访2年时,患者无疾病,功能结果良好。

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