Carew T E, Covell J W
Am J Cardiol. 1978 Jul;42(1):82-8. doi: 10.1016/0002-9149(78)90989-x.
Indexes of left ventricular function and diastolic compliance were studied in 10 awake exercise-trained greyhounds with left ventricular hypertrophy. Mean left ventricular to body weight ratio and mean myocardial cell diameter were significantly greater than in normal dogs (8.73 +/- 2.7 [standard error of the mean] versus 4.63 +/- 0.24 g/kg, P less than 0.01; and 18.3 +/- 0.67 versus 12.5 +/- 0.71 mu, P less than 0.01, respectively). In awake resting animals, 7 to 50 days after implantation of a high fidelity micromanometer and sonomicrometer crystals, left ventricular contractility indexes were similar to those measured previously in normal dogs (maximal derivative of left ventricular pressure [dP/dt] 3,800 +/- 250 versus 3,810 +/- 330 mm Hg/sec, difference not significant; and mean rate of circumferential fiber shortening 1.54 +/- 0.12 versus 1.43 +/- 0.12 sec-1, difference not significant). During volume loading sufficient to produce a left ventricular end-diastolic pressure of 20 mm Hg, changes in contractility indexes were similar to those in normal dogs; however, heart rate increased significantly (74 percent, P less than 0.005) in the trained greyhounds but not in normal dogs. Left ventricular diastolic stiffness did not differ from normal (51.6 +/- 3.0 versus 45.9 +/- 5.9 mm Hg/cm, P less than 0.01). These findings suggest that left ventricular function in exercise-induced left ventricular hypertrophy is substantially normal.
对10只清醒的、经运动训练且患有左心室肥厚的灵缇犬的左心室功能和舒张顺应性指标进行了研究。左心室与体重的平均比值以及平均心肌细胞直径显著大于正常犬（分别为8.73±2.7[平均标准误差]对4.63±0.24 g/kg，P<0.01；以及18.3±0.67对12.5±0.71μm，P<0.01）。在植入高保真微压计和超声微测晶体后的7至50天，清醒休息状态下的动物左心室收缩性指标与先前在正常犬中测得的相似（左心室压力最大变化率[dP/dt]为3800±250对3810±330 mmHg/秒，差异不显著；圆周纤维缩短平均速率为1.54±0.12对1.43±0.12秒⁻¹，差异不显著）。在容量负荷足以使左心室舒张末期压力达到20 mmHg的过程中，收缩性指标的变化与正常犬相似；然而，训练后的灵缇犬心率显著增加（74%，P<0.005），而正常犬则没有。左心室舒张硬度与正常情况无差异（51.6±3.0对45.9±5.9 mmHg/cm，P<0.01）。这些发现表明，运动诱导的左心室肥厚时左心室功能基本正常。
