Rippe J M, Pape L A, Alpert J S, Ockene I S, Paraskos J A, Kotilainen P, Anas J, Webster W
Basic Res Cardiol. 1982 Nov-Dec;77(6):619-44. doi: 10.1007/BF01908315.
Despite much interest in the effects of exercise on the myocardium, and the need to develop animal models which mimic conditions leading to cardiac hypertrophy, little attention has been focused on the trained racing greyhound. The current study compared two groups of anesthetized trained racing greyhounds (a total of 20 animals, 12 of whom were maintained for serial studies and 8 of whom were sacrificed for anatomic correlations) with 3 detrained greyhounds and 6 comparably sized mongrels. Systemic blood pressures, right and left heart pressures, ventricular mechanics and indices of diastolic behavior were compared. All measured indices of contractility (dp/dt, dp/dtDP40, Vce and Vmax) were lower in trained racing greyhounds than in mongrels although none achieved statistical significance. No significant difference in diastolic behavior was found between trained greyhounds and mongrels. While caution should be applied because of the small numbers of animals and the use of anesthesia, the lower than expected contractility found in trained racing greyhounds may reflect increased parasympathetic tone in the immediate post-training period. The normal diastolic behavior of the trained greyhound left ventricle contrasts to abnormal diastolic behavior found in models of chronic pressure overload.
尽管人们对运动对心肌的影响以及开发模拟导致心脏肥大状况的动物模型兴趣浓厚，但训练有素的赛犬却很少受到关注。当前研究将两组麻醉状态下的训练有素的赛犬（共20只动物，其中12只用于系列研究，8只用于解剖相关性研究）与3只脱训赛犬和6只体型相当的杂种犬进行了比较。比较了全身血压、左右心压力、心室力学和舒张行为指标。尽管训练有素的赛犬的所有收缩性测量指标（dp/dt、dp/dtDP40、Vce和Vmax）均低于杂种犬，但均未达到统计学意义。训练有素的赛犬和杂种犬之间的舒张行为未发现显著差异。尽管由于动物数量少和使用麻醉需要谨慎，但训练有素的赛犬收缩性低于预期可能反映了训练后即刻副交感神经张力增加。训练有素的赛犬左心室正常的舒张行为与慢性压力超负荷模型中发现的异常舒张行为形成对比。
