Perioli Luana, Ambrogi Valeria, Rubini Daniela, Giovagnoli Stefano, Ricci Maurizio, Blasi Paolo, Rossi Carlo
Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo, 1, Perugia 06123, Italy.
J Control Release. 2004 Mar 24;95(3):521-33. doi: 10.1016/j.jconrel.2003.12.018.
Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen tablet, containing 20 mg of metronidazole, performed 12 h drug sustained release with buccal concentrations always higher than its MIC.
制备了使用不同纤维素和聚丙烯酸衍生物混合物的粘膜粘附片，以获得含有甲硝唑用于治疗牙周疾病的新制剂。所有片剂均通过溶胀研究、体外和体内粘膜粘附时间、体外粘膜粘附力、体外和体内释放进行表征。通过使用羟乙基纤维素（HEC）和卡波姆940比例为2:2实现了最佳的粘膜粘附性能和最佳的体外药物释放曲线。所选择的含有20mg甲硝唑的片剂实现了12小时的药物持续释放，颊部浓度始终高于其最低抑菌浓度。
