Shah Mita M, Sampogna Rosemary V, Sakurai Hiroyuki, Bush Kevin T, Nigam Sanjay K
Department of Pediatrics, University of California, San Diego, CA 92093-0693, USA.
Development. 2004 Apr;131(7):1449-62. doi: 10.1242/dev.01089.
Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to human diseases. It discusses how the broad organization of molecular interactions during kidney development might provide a mechanistic framework for understanding disorders related to aberrant branching.
肾脏中的分支形态发生是一个受到严格调控的复杂过程，其破坏可能会导致一系列广泛的疾病，从罕见的遗传综合征到常见病症，如高血压和慢性肾衰竭。本综述综合了来自体外和体内啮齿动物研究的肾脏发育过程中分支的数据，并将其应用于人类疾病。它讨论了肾脏发育过程中分子相互作用的广泛组织如何可能为理解与异常分支相关的疾病提供一个机制框架。
