Aref Mohamed, Abd-Almotaleb Noha Ali, Elsheikh Eman H, Salem Gamal A, Nassan Mohamed A, Elsheikh Esraa
Department of Anatomy and Embryology, Faculty of Veterinary medicine, Zagazig University, Al-Sharqia, Egypt.
Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Al-Sharqia, Egypt.
Open Vet J. 2025 Feb;15(2):738-745. doi: 10.5455/OVJ.2025.v15.i2.23. Epub 2025 Feb 28.
Rabbits are easily available and docile animals; thus, they are a promising model for medical research. White New Zealand rabbits are usually employed for research.
This study aimed to determine the kidney's histological structure using rabbit embryos and fetuses at various stages of gestation.
Morphogenesis and histogenesis of the kidney were assessed using Harris's hematoxylin and eosin staining at different gestational periods in rabbits.
Around the 10th day of gestation, the intermediate mesoderm started to differentiate into kidney tissue. The first primitive form of the kidney was the pronephros, which consisted of pronephric tubules and ducts. Large mesonephroi occupied a large part of the abdominal cavity from the 13th day of gestation and persisted for several days. At 15th day of gestation, the permanent kidney, the metanephros, began its differentiation and then persevered until formation of the adult kidney tissue at 24th day of gestation.
This study clarified normal kidney histogenesis in rabbits; this would provide better understanding of kidney diseases aid in kidney transplant.
兔子是容易获得且温顺的动物，因此，它们是医学研究中很有前景的模型。通常使用新西兰白兔进行研究。
本研究旨在利用处于不同妊娠阶段的兔胚胎和胎儿来确定肾脏的组织学结构。
在兔子的不同妊娠期，使用苏木精-伊红染色法评估肾脏的形态发生和组织发生。
在妊娠第10天左右，中间中胚层开始分化为肾脏组织。肾脏的第一种原始形式是前肾，由前肾小管和前肾管组成。从妊娠第13天开始，大型中肾占据腹腔的很大一部分，并持续数日。在妊娠第15天，永久性肾脏即后肾开始分化，随后持续发育，直至在妊娠第24天形成成年肾脏组织。
本研究阐明了兔子正常的肾脏组织发生过程；这将有助于更好地理解肾脏疾病并辅助肾脏移植。
