Lu Pei-Chen, Tain You-Lin, Lin Ying-Jui, Hsu Chien-Ning
Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.
Antioxidants (Basel). 2025 Mar 26;14(4):387. doi: 10.3390/antiox14040387.
Kidney disease and hypertension are interconnected, prevalent conditions that affect both pregnant women and children. Oxidative stress occurs when reactive oxygen species or reactive nitrogen species exceed the capacity of antioxidant systems. It plays a critical role in kidney development, resulting in kidney programming and increased risks for kidney disease and hypertension across the life course. Animal models have significantly advanced our understanding of oxidative stress-related kidney programming, the molecular mechanisms involved, and early-life antioxidant interventions to prevent kidney disease. This review critically examines the influence of perinatal oxidative stress on kidney development, highlighting its long-term effects on kidney outcomes and susceptibility to hypertension. It also explores the potential of antioxidant-based interventions in preventing kidney disease and hypertension. Furthermore, the review addresses the existing gap between insights gained from animal models and their translation into clinical practices, emphasizing the challenges and opportunities for future research in this area.
肾脏疾病和高血压相互关联，是影响孕妇和儿童的常见病症。当活性氧或活性氮超过抗氧化系统的能力时，就会发生氧化应激。它在肾脏发育中起关键作用，导致肾脏编程，并增加一生中患肾脏疾病和高血压的风险。动物模型显著推进了我们对氧化应激相关肾脏编程、所涉及的分子机制以及预防肾脏疾病的早期抗氧化干预措施的理解。本综述批判性地研究了围产期氧化应激对肾脏发育的影响，强调了其对肾脏结局和高血压易感性的长期影响。它还探讨了基于抗氧化剂的干预措施在预防肾脏疾病和高血压方面的潜力。此外，该综述阐述了从动物模型中获得的见解与将其转化为临床实践之间存在的差距，强调了该领域未来研究的挑战和机遇。
