Imanaka-Yoshida K, Hiroe M, Yoshida T
Department of Pathology, Mie University School of Medicine, Tsu, Japan.
Histol Histopathol. 2004 Apr;19(2):517-25. doi: 10.14670/HH-19.517.
The heart remodels myocardial tissue in physiological and pathological response. The cell-extracellular matrix (ECM) interaction provides not only structural and mechanical support but also important biological signaling during tissue remodeling. Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cancer progression. In the heart, TNC appears in several important steps of embryonic development such as the initial differentiation of cardiomyocytes or coronary vasculo/angiogenesis, but it is not detected in a normal adult myocardium. However, TNC is found to re-express after myocardial injury and may regulate cellular behavior during tissue remodeling by modulating the attachment of cardiomyocytes to connective tissue, by enhancing migration and differentiation of myofibroblasts, and by inducing matrix metallo-proteinases. TNC also interacts with other ECM molecules and may modulate progression of fibrosis. Furthermore, transient and site specific expression of TNC closely associated with myocardial injury and inflammation suggests not only its key roles during tissue remodeling but also that TNC can be a marker for myocardial disease activity.
心脏在生理和病理反应中重塑心肌组织。细胞与细胞外基质（ECM）的相互作用不仅提供结构和机械支持，还在组织重塑过程中提供重要的生物信号。在各种ECM分子中，腱生蛋白-C（TNC）作为胚胎发育、伤口愈合或癌症进展过程中多种细胞功能的调节因子而广为人知。在心脏中，TNC出现在胚胎发育的几个重要步骤中，如心肌细胞的初始分化或冠状血管生成，但在正常成年心肌中未检测到。然而，TNC在心肌损伤后重新表达，并可能通过调节心肌细胞与结缔组织的附着、增强肌成纤维细胞的迁移和分化以及诱导基质金属蛋白酶来调节组织重塑过程中的细胞行为。TNC还与其他ECM分子相互作用，并可能调节纤维化进程。此外，TNC与心肌损伤和炎症密切相关的瞬时和位点特异性表达不仅表明其在组织重塑过程中的关键作用，还表明TNC可以作为心肌疾病活动的标志物。
