Maulik Nilanjana
Molecular Cardiology Laboratory, Department of Surgery, University of Connecticut Medical Center, Farmington, CT, USA.
Antioxid Redox Signal. 2004 Apr;6(2):413-21. doi: 10.1089/152308604322899486.
Angiogenesis represents a major focus for novel therapeutic approaches to the prevention and treatment of multiple diseases, most notably ischemic cardiovascular disease and cancer. Therapeutic angiogenesis achieved either through the use of discreet angiogenic proteins or by gene therapy is fast emerging as a highly attractive treatment modality for ischemic heart disease. The purpose of this review is to address this important clinical issue through the identification of potential signaling mechanisms by which a short episode of sublethal ischemia known as ischemic preconditioning causes angiogenesis and subsequently improves myocardial salvage following coronary artery occlusion.
血管生成是预防和治疗多种疾病（尤其是缺血性心血管疾病和癌症）的新型治疗方法的主要关注点。通过使用特定的血管生成蛋白或基因疗法实现的治疗性血管生成正迅速成为缺血性心脏病极具吸引力的治疗方式。本综述的目的是通过确定潜在的信号传导机制来解决这一重要的临床问题，即短暂的亚致死性缺血（称为缺血预处理）通过该机制导致血管生成，并随后改善冠状动脉闭塞后的心肌挽救。
