Maulik Nilanjana
Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Medical Center, Farmington, Connecticut 06030-1110, USA.
Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2161-8. doi: 10.1089/ars.2006.8.2161.
Neovascularization, the natural physiological process of formation of new blood vessels, is extremely important for ameliorating the function of the heart that undergoes ischemic stress. This process is potentially important for the treatment of ischemic heart and limb diseases, which includes formation of capillaries (angiogenesis) and collateral arteries. Ischemia or coronary artery occlusion induces vascular endothelial growth factor (VEGF) in the experimental rat myocardial infarction model, and this molecule encourages development of coronary collateral circulation and retention of the blood supply to the ischemic area. Restoration of the blood supply to the ischemic area prevents cardiomyocyte death and cardiac remodeling. Among the various triggers and enhancers of angiogenesis, hypoxic or ischemic preconditioning, as well as pharmacologic agents such as statin and resveratrol, have been identified as important stimuli for the induction of new vessel growth. It has already been demonstrated that the VEGF family and its receptor system is the fundamental regulator in the redox cell signaling of angiogenesis. This review article will focus on the role of reactive oxygen species in the process of myocardial angiogenesis.
新生血管形成是新血管形成的自然生理过程，对于改善遭受缺血应激的心脏功能极为重要。这一过程对于缺血性心脏和肢体疾病的治疗具有潜在重要性，包括毛细血管（血管生成）和侧支动脉的形成。在实验性大鼠心肌梗死模型中，缺血或冠状动脉闭塞会诱导血管内皮生长因子（VEGF），该分子促进冠状动脉侧支循环的发展以及对缺血区域的血液供应维持。恢复缺血区域的血液供应可防止心肌细胞死亡和心脏重塑。在血管生成的各种触发因素和增强因素中，缺氧或缺血预处理以及他汀类药物和白藜芦醇等药物已被确定为诱导新血管生长的重要刺激因素。已经证明，VEGF家族及其受体系统是血管生成氧化还原细胞信号传导的基本调节因子。这篇综述文章将聚焦于活性氧在心肌血管生成过程中的作用。
