Wu Yao-Pan, Cai Pei-Qiang, Zhang Wei-Zhang, Tang Jun, Gu Yang-Kui, Li Li, Ouyang Yi, He Jie-Hua, Lin Hao-Gao
Department of Diagnostic Imaging & Intervention, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China.
Ai Zheng. 2004 Mar;23(3):346-9.
BACKGROUND & OBJECTIVE: Early detection of breast cancer is crucial to improve the therapeutic effect and to increase the survival rate. However, it is difficult because breast cancer in early stage was usually occult, impalpable, and could not be detected by laboratory test. This study was designed to compare the effectiveness of three methods for diagnosis of non-palpable breast cancer.
Twenty-four patients with impalpable breast mass suggested by computer-aided stereotactic mammography were performed with three kinds of methods, including fine-needle aspiration cytology (FNAC), large-core needle biopsy (LCNB), and frozen section biopsy (FSB) with focus staining. The results were compared with postoperative pathology.
Compared with postoperative pathology results, the diagnostic consistent rates of FNAC, LCNB and FSB with staining focus were 75%, 92%, and 100%, respectively (P< 0.05).
Frozen section with focus staining guided by computer-aided stereotactic mammography was the effective diagnostic technique for non-palpable breast cancer.
早期发现乳腺癌对于提高治疗效果和生存率至关重要。然而，这存在困难，因为早期乳腺癌通常隐匿、触诊不到且无法通过实验室检查检测到。本研究旨在比较三种诊断不可触及乳腺癌方法的有效性。
对24例经计算机辅助立体定向乳腺摄影提示有不可触及乳腺肿块的患者采用三种方法进行检查，包括细针穿刺细胞学检查（FNAC）、粗针活检（LCNB）和聚焦染色冰冻切片活检（FSB）。将结果与术后病理结果进行比较。
与术后病理结果相比，FNAC、LCNB和聚焦染色FSB的诊断符合率分别为75%、92%和100%（P<0.05）。
计算机辅助立体定向乳腺摄影引导下的聚焦染色冰冻切片是诊断不可触及乳腺癌的有效诊断技术。
