Wang Xiu-Shen, Liu Meng-Zhong, Hu Yong-Hong
Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China.
Ai Zheng. 2004 Mar;23(3):358-60.
With the development of multidisciplinary treatment for cancer, great changes have taken place in the therapeutic strategy of breast cancer. However, radiotherapy as a method of local management, still plays an important role in the combined treatment of breast cancer. The recurrence in the chest wall ranks the first, accounting for 44-69% of the total local-regional relapse, therefore, the chest wall is commonly regarded as the most important target of radiotherapy after mastectomy. The traditional irradiation techniques cannot reach an ideal dose distribution due to the irregular shape of the chest wall. Electron arc therapy, by using the electron characteristics of dose distribution, combining the shape of thorax and the depth of target volume, make the dose distribution of target volume more reasonable, decreases the dose of heart or lung and has more clinical benefit than traditional techniques. On the other hand, it had been demonstrated by some clinical research that irradiation with electron arc could provide a high rate of local control and generally acceptable acute and long-term toxicity, comparing with the traditional irradiation techniques.
随着癌症多学科治疗的发展,乳腺癌的治疗策略发生了巨大变化。然而,放射治疗作为一种局部治疗方法,在乳腺癌的综合治疗中仍发挥着重要作用。胸壁复发位居首位,占局部区域复发总数的44%-69%,因此,胸壁通常被视为乳房切除术后放疗的最重要靶区。由于胸壁形状不规则,传统照射技术无法达到理想的剂量分布。电子弧形治疗利用剂量分布的电子特性,结合胸廓形状和靶区深度,使靶区剂量分布更合理,减少心脏或肺部的剂量,比传统技术具有更多的临床益处。另一方面,一些临床研究表明,与传统照射技术相比,电子弧形照射可提供较高的局部控制率,且急性和长期毒性普遍可接受。