Palani Anandan, Dugar Sundeep, Clader John W, Greenlee William J, Ruperto Vilma, Duffy Ruth A, Lachowicz Jean E
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett. 2004 Apr 5;14(7):1791-4. doi: 10.1016/j.bmcl.2004.01.033.
Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1.
合成了低分子量酰胺衍生物，并将其作为M(2)受体拮抗剂进行评估，用于治疗阿尔茨海默病。异丙基酰胺19和31是高效、选择性的低分子量M(2)受体拮抗剂，其结构特征与我们的临床候选药物1不同。
